Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells.

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作者： Yaara,Cohen-Hadad ^[1] ; Gheona,Altarescu ^[2] ; Talia,Eldar-Geva ^[3] ; Ephrat,Levi-Lahad ^[2] ; Ming,Zhang ^[4] ; Ekaterina,Rogaeva ^[4] ; Marc,Gotkine ^[5] ; Osnat,Bartok ^[6] ; Reut,Ashwal-Fluss ^[6] ; Sebastian,Kadener ^[6] ; Silvina,Epsztejn-Litman ^[1] ; Rachel,Eiges ^[7]

作者单位： Stem Cell Research Laboratory, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem 91031, Israel. ^[1] Zohar PGD Laboratory, Medical Genetics Institute, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem 91031, Israel. ^[2] IVF Unit, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem 91031, Israel. ^[3] Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON MSS 3H2, Canada. ^[4] Department of Neurology, Hadassah Medical Center, Hebrew University, Jerusalem 91120, Israel. ^[5] Biological Chemistry Department, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. ^[6] Stem Cell Research Laboratory, Shaare Zedek Medical Center, Hebrew University School of Medicine, Jerusalem 91031, Israel. Electronic address: rachela@szmc.org.il. ^[7]

关键词 C9/ALS CpG islands DNA methylation disease modelling neurodegeneration pluripotent stem cells unstable repeat expansions

主题词选择性剪接(Alternative Splicing);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);细胞分化(Cell Differentiation);细胞系(Cell Line);CpG岛(CpG Islands);DNA甲基化(DNA Methylation);胚胎干细胞(Embryonic Stem Cells);基因表达调控, 发育期(Gene Expression Regulation, Developmental);单倍型(Haplotypes);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells)

DOI 10.1016/j.stemcr.2016.09.011

PMID 27773700

发布时间 2018-11-13

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Stem cell reports

2016年7卷5期

927-940页

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Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells.

Stem cell reports

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Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells.

Stem cell reports

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Stem cell reports

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