Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

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作者： Miriam,Rothdiener ^[1] ; Miriam,Hegemann ^[2] ; Tatiana,Uynuk-Ool ^[1] ; Brandan,Walters ^[3] ; Piruntha,Papugy ^[1] ; Phong,Nguyen ^[1] ; Valentin,Claus ^[1] ; Tanja,Seeger ^[4] ; Ulrich,Stoeckle ^[5] ; Karen A,Boehme ^[6] ; Wilhelm K,Aicher ^[2] ; Jan P,Stegemann ^[3] ; Melanie L,Hart ^[7] ; Bodo,Kurz ^[8] ; Gerd,Klein ^[4] ; Bernd,Rolauffs ^[7]

作者单位： Siegfried Weller Institute for Trauma Research, BG Trauma Clinic Tuebingen, University of Tuebingen, Germany. ^[1] Department of Urology, University of Tuebingen, Germany. ^[2] Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. ^[3] Center for Medical Research, Medical University Clinic II, University of Tuebingen, Germany. ^[4] Clinic for Trauma and Restorative Surgery, BG Trauma Clinic Tuebingen, University of Tuebingen, Germany. ^[5] Department of Orthopaedic Surgery, University of Tuebingen, Germany. ^[6] Department of Orthopedics and Trauma Surgery, Albert-Ludwigs-University, Freiburg, Germany. ^[7] Department of Anatomy, Christian-Albrechts-University, Kiel, Germany. ^[8]

主题词肌动蛋白类(Actins);骨髓细胞(Bone Marrow Cells);钙结合蛋白质类(Calcium-Binding Proteins);细胞培养技术(Cell Culture Techniques);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);胶原Ⅰ型(Collagen Type I);基因表达调控(Gene Expression Regulation);人类(Humans);间质干细胞(Mesenchymal Stem Cells);微丝蛋白质类(Microfilament Proteins);显微镜检查, 原子力(Microscopy, Atomic Force);肌蛋白质类(Muscle Proteins);肌, 平滑(Muscle, Smooth);表型(Phenotype);微管蛋白(Tubulin)

DOI 10.1038/srep35840

PMID 27775041

发布时间 2023-12-13

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Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

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Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

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