Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation.

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作者： Júlia L,Monteiro ^[1] ; Paula F,Carneiro ^[1] ; Petteri,Elsner ^[2] ; Dominique M,Roberge ^[2] ; Peter G M,Wuts ^[3] ; Katherine C,Kurjan ^[4] ; Bernhard,Gutmann ^[5] ; C Oliver,Kappe ^[1]

作者单位： Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, 8010, Graz, Austria. ^[1] Chemical Manufacturing Technologies, Lonza AG, 3930, Visp, Switzerland. ^[2] Kalexsyn, Inc., 4502 Campus Drive, Kalamazoo, MI, 49008, USA. ^[3] Wuts Chemistry Consulting, 5287 Saddle Club Drive, Kalamazoo, MI, 49009, USA. ^[4] Allergan plc, 2525 Dupont Drive, Irvine, CA, 92612, USA. ^[5] Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010, Graz, Austria. ^[6]

关键词 Fenton reagent Minisci reaction flow chemistry radical reactions trifluoromethylation

DOI 10.1002/chem.201604579

PMID 27775849

发布时间 2017-09-18

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准确一般字义偏差语意偏离译文作用小提交