首页> Genetics> Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast.

Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast.

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第一作者： Milo B,Fasken

第一单位： Department of Biology, Emory University, Atlanta, Georgia 30322.

作者： Milo B,Fasken ^[1] ; Jillian S,Losh ^[2] ; Sara W,Leung ^[1] ; Sergine,Brutus ^[3] ; Brittany,Avin ^[4] ; Jillian C,Vaught ^[5] ; Jennifer,Potter-Birriel ^[6] ; Taylor,Craig ^[1] ; Graeme L,Conn ^[7] ; Katherine,Mills-Lujan ^[1] ; Anita H,Corbett ^[8] ; Ambro,van Hoof ^[9]

作者单位： Department of Biology, Emory University, Atlanta, Georgia 30322. ^[1] Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Texas 77030.;The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030. ^[2] Department of Biology, Emory University, Atlanta, Georgia 30322.;Emory Initiative for Maximizing Student Diversity, Emory University, Atlanta, Georgia 30322. ^[3] Department of Biology, Emory University, Atlanta, Georgia 30322.;Emory Summer Undergraduate Research Experience Program, Emory University, Atlanta, Georgia 30322. ^[4] Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Texas 77030. ^[5] Department of Biology, Emory University, Atlanta, Georgia 30322.;Emory Postbaccalaureate Training Program, Emory University, Atlanta, Georgia 30322. ^[6] Department of Biochemistry. ^[7] Department of Biology, Emory University, Atlanta, Georgia 30322 acorbe2@emory.edu Ambro.van.hoof@uth.tmc.edu. ^[8] Department of Microbiology and Molecular Genetics, University of Texas Health Science Center-Houston, Texas 77030 acorbe2@emory.edu Ambro.van.hoof@uth.tmc.edu.;The University of Texas Graduate School of Biomedical Sciences, Houston, Texas 77030. ^[9]

关键词 EXOSC2 EXOSC3 RNA exosome RNA processing/degradation Rrp40 pontocerebellar hypoplasia type 1b

医学主题词小脑疾病(Cerebellar Diseases);外切核糖核酸酶类(Exoribonucleases);突变(Mutation);RNA稳定性(RNA Stability);RNA结合蛋白质类(RNA-Binding Proteins);酿酒酵母菌(Saccharomyces cerevisiae);酿酒酵母蛋白质类(Saccharomyces cerevisiae Proteins)

DOI 10.1534/genetics.116.195917

PMID 27777260

发布时间 2020-12-09

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