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5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers.

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第一作者： Lauren,Van Der Kraak

第一单位： Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA USA.

作者： Lauren,Van Der Kraak ^[1] ; Gaurav,Goel ^[2] ; Krishnaveni,Ramanan ^[3] ; Christof,Kaltenmeier ^[3] ; Lin,Zhang ^[4] ; Daniel P,Normolle ^[5] ; Gordon J,Freeman ^[6] ; Daolin,Tang ^[3] ; Katie S,Nason ^[1] ; Jon M,Davison ^[7] ; James D,Luketich ^[1] ; Rajeev,Dhupar ^[1] ; Michael T,Lotze ^[8]

作者单位： Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA USA. ^[1] Department of Medicine, Division of Hematology-Oncology, University of Pittsburgh, Pittsburgh, PA USA.;Current address: Division of Medical Oncology, University of Kentucky Markey Cancer Center, Lexington, KY USA. ^[2] Department of Surgery, University of Pittsburgh, Pittsburgh, PA USA. ^[3] Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA USA. ^[4] Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA USA. ^[5] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA USA. ^[6] Department of Pathology, University of Pittsburgh, Pittsburgh, PA USA. ^[7] Department of Surgery, University of Pittsburgh, Pittsburgh, PA USA.;Department of Immunology, University of Pittsburgh, Pittsburgh, PA USA.;Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA USA. ^[8]

关键词 5-Fluorouracil B7-H1 Checkpoint blockade Digestive cancers Immunotherapy PD-1 PD-L1

医学主题词腺癌(Adenocarcinoma);抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);Barrett食管(Barrett Esophagus);活组织检查(Biopsy);细胞系, 肿瘤(Cell Line, Tumor);细胞膜(Cell Membrane);食管肿瘤(Esophageal Neoplasms);流式细胞术(Flow Cytometry);氟尿嘧啶(Fluorouracil);胃肠肿瘤(Gastrointestinal Neoplasms);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲除技术(Gene Knockout Techniques);人类(Humans);免疫组织化学(Immunohistochemistry);干扰素γ(Interferon-gamma);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1186/s40425-016-0163-8

PMID 27777774

发布时间 2025-06-21

基金项目

K07 CA151613/CA/NCI NIH HHS/United States P30 CA047904/CA/NCI NIH HHS/United States R01 CA160417/CA/NCI NIH HHS/United States R01 CA181450/CA/NCI NIH HHS/United States

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Journal for immunotherapy of cancer

2016年4卷

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Journal for immunotherapy of cancer

2016年4卷

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5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers.

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5-Fluorouracil upregulates cell surface B7-H1 (PD-L1) expression in gastrointestinal cancers.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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