Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis.

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作者： Arnaldo N S,Silva ^[1] ; Jordy,Coffa ^[2] ; Varsha,Menon ^[3] ; Lindsay C,Hewitt ^[4] ; Kakoli,Das ^[5] ; Yohei,Miyagi ^[6] ; Dan,Bottomley ^[1] ; Hayley,Slaney ^[1] ; Toru,Aoyama ^[7] ; Wolfram,Mueller ^[8] ; Tomio,Arai ^[9] ; Iain B,Tan ^[10] ; Niantao,Deng ^[11] ; Xiu B,Chan ^[12] ; Patrick,Tan ^[5] ; Akira,Tsuburaya ^[13] ; Kentaro,Sakamaki ^[14] ; Jeremy D,Hayden ^[15] ; Takaki,Yoshikawa ^[7] ; Ilse,Zondervan ^[2] ; Suvi,Savola ^[2] ; Heike I,Grabsch ^[1]

作者单位： Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom. ^[1] MRC-Holland B.V, Research and Development Department, Amsterdam, The Netherlands. ^[2] Drug Design and Discovery Group, Sharjah Institute for Medical Research, University of Sharjah, United Arab Emirates. ^[3] Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. ^[4] Duke-NUS Medical School, Singapore. ^[5] Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan. ^[6] Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan. ^[7] Gemeinschaftspraxis Pathologie, Starnberg, Germany. ^[8] Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan. ^[9] Division of Medical Oncology, National Cancer Centre, Singapore. ^[10] Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore. ^[11] Genome Institute of Singapore, Singapore. ^[12] Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan. ^[13] Department of Biostatistics and Epidemiology, Yokohama City University, Yokohama, Japan. ^[14] Department of Upper Gastrointestinal Surgery, Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom. ^[15]