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Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis.

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第一作者： Indra,Sandal

第一单位： Research Service, Memphis VA Medical Center, 1030 Jefferson Avenue, Memphis, TN, 38104, USA.

作者： Indra,Sandal ^[1] ; Anastasios,Karydis ^[2] ; Jiwen,Luo ^[3] ; Amanda,Prislovsky ^[1] ; Karen B,Whittington ^[1] ; Edward F,Rosloniec ^[4] ; Chen,Dong ^[5] ; Deborah V,Novack ^[6] ; Piotr,Mydel ^[7] ; Song Guo,Zheng ^[8] ; Marko Z,Radic ^[9] ; David D,Brand ^[10]

作者单位： Research Service, Memphis VA Medical Center, 1030 Jefferson Avenue, Memphis, TN, 38104, USA. ^[1] Department of Periodontology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. ^[2] Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. ^[3] Research Service, Memphis VA Medical Center, 1030 Jefferson Avenue, Memphis, TN, 38104, USA.;Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.;Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. ^[4] Institute for Immunology, Tsinghua University, Beijing, 100084, China. ^[5] Musculoskeletal Research Center, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, MO, 63110, USA. ^[6] Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway. ^[7] Division of Rheumatology, Department of Medicine, Pennsylvania State University Hershey College of Medicine, Hershey, PA, 17033, USA. ^[8] Department of Microbiology Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. ^[9] Research Service, Memphis VA Medical Center, 1030 Jefferson Avenue, Memphis, TN, 38104, USA. David.Brand@va.gov.;Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. David.Brand@va.gov.;Department of Microbiology Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. David.Brand@va.gov. ^[10]

关键词 Animal model Periodontal disease Porphyromonas gingivalis Rheumatoid arthritis