Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.

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第一作者： Fayez,Hadji

第一单位： From Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery (F.H., M.-C.B, N.G., S.A., G.M., R.B., M.J.N., P.M.), Department of Molecular Medicine (J.T.M., S.G.-O., Y.B.), and Department of Medicine (P.P.), Laval University, Quebec, QC, Canada; Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada (S.-P.G., L.B.); and ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada (S.-P.G., L.B.).

作者： Fayez,Hadji ^[1] ; Marie-Chloé,Boulanger ^[1] ; Simon-Pierre,Guay ^[1] ; Nathalie,Gaudreault ^[1] ; Soumiya,Amellah ^[1] ; Guada,Mkannez ^[1] ; Rihab,Bouchareb ^[1] ; Joël Tremblay,Marchand ^[1] ; Mohamed Jalloul,Nsaibia ^[1] ; Sandra,Guauque-Olarte ^[1] ; Philippe,Pibarot ^[1] ; Luigi,Bouchard ^[1] ; Yohan,Bossé ^[1] ; Patrick,Mathieu ^[2]

作者单位： From Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery (F.H., M.-C.B, N.G., S.A., G.M., R.B., M.J.N., P.M.), Department of Molecular Medicine (J.T.M., S.G.-O., Y.B.), and Department of Medicine (P.P.), Laval University, Quebec, QC, Canada; Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada (S.-P.G., L.B.); and ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada (S.-P.G., L.B.). ^[1] From Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery (F.H., M.-C.B, N.G., S.A., G.M., R.B., M.J.N., P.M.), Department of Molecular Medicine (J.T.M., S.G.-O., Y.B.), and Department of Medicine (P.P.), Laval University, Quebec, QC, Canada; Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada (S.-P.G., L.B.); and ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada (S.-P.G., L.B.). patrick.mathieu@fmed.ulaval.ca yohan.bosse@criucpq.ulaval.ca. ^[2]

关键词 H19 long non-coding RNA RNA, long noncoding aortic valve aortic valve stenosis aortic valve, calcification of core binding factor alpha 1 subunit receptor, notch1