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首页> Biochemical and biophysical research communications> Lead discovery for mammalian elongation of long chain fatty acids family 6 using a combination of high-throughput fluorescent-based assay and RapidFire mass spectrometry assay.

Lead discovery for mammalian elongation of long chain fatty acids family 6 using a combination of high-throughput fluorescent-based assay and RapidFire mass spectrometry assay.

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作者： Mari,Takamiya ^[1] ; Masaaki,Sakurai ^[2] ; Fumie,Teranishi ^[2] ; Tomoko,Ikeda ^[2] ; Tsutomu,Kamiyama ^[3] ; Akira,Asai ^[4]

作者单位： Centre for Drug Discovery, Graduate School of Pharmaceutical Science, University of Shizuoka, Suruga-ku, Shizuoka, Shizuoka, Japan; Discovery Technology Laboratories, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kawagishi, Toda-shi, Saitama, Japan. ^[1] Advanced Drug Research Laboratories, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kawagishi, Toda-shi, Saitama, Japan. ^[2] Discovery Technology Laboratories, Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Kawagishi, Toda-shi, Saitama, Japan. ^[3] Centre for Drug Discovery, Graduate School of Pharmaceutical Science, University of Shizuoka, Suruga-ku, Shizuoka, Shizuoka, Japan. Electronic address: aasai@u-shizuoka-ken.ac.jp. ^[4]

关键词 Drug discovery Elongation of long chain fatty acids family 6 (Elovl6)High-throughput screening (HTS)RapidFire mass spectrometry (RF-MS)

主题词乙酰基转移酶类(Acetyltransferases);药物评价, 临床前(Drug Evaluation, Preclinical);高通量筛选分析(High-Throughput Screening Assays);质谱分析法(Mass Spectrometry);药用制剂(Pharmaceutical Preparations);结果可重复性(Reproducibility of Results);敏感性与特异性(Sensitivity and Specificity);光谱法, 荧光(Spectrometry, Fluorescence)

DOI 10.1016/j.bbrc.2016.10.103

PMID 27793673

发布时间 2019-12-10

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Biochemical and biophysical research communications

Biochemical and biophysical research communications

2016年480卷4期

721-726页

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Biochemical and biophysical research communications

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Biochemical and biophysical research communications

2016年480卷4期

721-726页

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