IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.-论文-万方医学网

第一作者： Thomas A,Mace

第一单位： Divisions of Medical Oncology and Gastroenterology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.

作者： Thomas A,Mace ^[1] ; Reena,Shakya ^[2] ; Jason R,Pitarresi ^[3] ; Benjamin,Swanson ^[4] ; Christopher W,McQuinn ^[1] ; Shannon,Loftus ^[1] ; Emily,Nordquist ^[1] ; Zobeida,Cruz-Monserrate ^[1] ; Lianbo,Yu ^[5] ; Gregory,Young ^[6] ; Xiaoling,Zhong ^[7] ; Teresa A,Zimmers ^[7] ; Michael C,Ostrowski ^[3] ; Thomas,Ludwig ^[3] ; Mark,Bloomston ^[8] ; Tanios,Bekaii-Saab ^[9] ; Gregory B,Lesinski ^[10]

作者单位： Divisions of Medical Oncology and Gastroenterology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. ^[1] Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA. ^[2] Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA. ^[3] Department of Pathology, The Ohio State University, Columbus, Ohio, USA. ^[4] Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA. ^[5] Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA. ^[6] Department of Surgery (Indiana University) and IU Simon Cancer Center, The Ohio State University, Columbus, Ohio, USA. ^[7] Division of Surgical Oncology, Department of Surgery, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, Ohio, USA. ^[8] Mayo Clinic, 5777 E. Mayo Blvd, Phoenix, Arizona, USA. ^[9] Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA. ^[10]

主题词肌动蛋白类(Actins);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);癌, 胰腺管(Carcinoma, Pancreatic Ductal);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);女(雌)性(Female);人类(Humans);白细胞介素6(Interleukin-6);Janus激酶类(Janus Kinases);L选择素(L-Selectin);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);胰腺肿瘤(Pancreatic Neoplasms);胰腺星形细胞(Pancreatic Stellate Cells);STAT转录因子类(STAT Transcription Factors);存活率(Survival Rate);Th1细胞(Th1 Cells);肿瘤微环境(Tumor Microenvironment);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1136/gutjnl-2016-311585

PMID 27797936

发布时间 2019-02-01

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IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

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IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

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