The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.

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作者： Kristie-Ann,Dickson ^[1] ; Alexander J,Cole ^[1] ; Anthony J,Gill ^[2] ; Adele,Clarkson ^[2] ; Gregory B,Gard ^[3] ; Angela,Chou ^[4] ; Catherine J,Kennedy ^[5] ; Beric R,Henderson ^[6] ; Australian Ovarian Cancer Study (AOCS) ^[6] ; Sian,Fereday ^[7] ; Nadia,Traficante ^[7] ; Kathryn,Alsop ^[7] ; David D,Bowtell ^[7] ; Anna,deFazio ^[8] ; Roderick,Clifton-Bligh ^[9] ; Deborah J,Marsh ^[5]

作者单位： Hormones and Cancer Group, Kolling Institute of Medical Research, Royal North Shore Hosptial, University of Sydney, St Leonards, NSW, Australia. ^[1] Department of Anatomical Pathology, Royal North Shore Hospital, University of Sydney, Sydney NSW, and Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia. ^[2] Department of Obstetrics and Gynaecology, Royal North Shore Hospital, St Leonards, NSW, Australia. ^[3] Department of Anatomical Pathology, SYDPATH, St Vincents Hospitals, Darlinghurst, NSW, Australia. ^[4] Department of Gynaecological Oncology, Westmead Hospital, Westmead, NSW, Australia. ^[5] Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW, Australia. ^[6] Cancer Genomics Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. ^[7] The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia and. ^[8] The Kinghorn Cancer Centre and Garvan Institute, Darlinghurst, NSW, Australia. ^[9]