Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.-论文-万方医学网

作者： Xuan,Yuan ^[1] ; Eleni,Gavriilaki ^[1] ; Jane A,Thanassi ^[2] ; Guangwei,Yang ^[2] ; Andrea C,Baines ^[1] ; Steven D,Podos ^[2] ; Yongqing,Huang ^[2] ; Mingjun,Huang ^[2] ; Robert A,Brodsky ^[3]

作者单位： Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[1] Achillion Pharmaceuticals, New Haven, CT, USA. ^[2] Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA rbrodsky@jhmi.edu. ^[3]

主题词成年人(Adult);老年人(Aged);动物(Animals);补体C3(Complement C3);补体因子D(Complement Factor D);补体灭活剂(Complement Inactivating Agents);补体途径, 旁路(Complement Pathway, Alternative);细胞毒性, 免疫(Cytotoxicity, Immunologic);疾病模型, 动物(Disease Models, Animal);红细胞(Erythrocytes);女(雌)性(Female);血红蛋白尿, 阵发性(Hemoglobinuria, Paroxysmal);溶血(Hemolysis);人类(Humans);成束猴(Macaca fascicularis);男(雄)性(Male);中年人(Middle Aged);蛋白质结合(Protein Binding);治疗结果(Treatment Outcome);青年人(Young Adult)

DOI 10.3324/haematol.2016.153312

PMID 27810992

发布时间 2019-07-09

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Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Haematologica

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Haematologica

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Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Haematologica

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Haematologica

相关期刊

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