The plasma membrane Ca<sup>2+</sup> pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.

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作者： Luca,Hegedũs ^[1] ; Tamás,Garay ^[2] ; Eszter,Molnár ^[3] ; Karolina,Varga ^[2] ; Ágnes,Bilecz ^[2] ; Szilvia,Török ^[2] ; Rita,Padányi ^[4] ; Katalin,Pászty ^[2] ; Matthias,Wolf ^[5] ; Michael,Grusch ^[6] ; Enikõ,Kállay ^[6] ; Balázs,Döme ^[1] ; Walter,Berger ^[4] ; Balázs,Hegedũs ^[7] ; Agnes,Enyedi ^[8]

作者单位： Department of Pathophysiology and Allergy Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria. ^[1] 2nd Department of Pathology, Semmelweis University, Budapest, Hungary. ^[2] Department of Biological Physics, Eötvös University, Budapest, Hungary. ^[3] National Koranyi Institute of Pulmonology, Budapest, Hungary. ^[4] Molecular Biophysics Research Group of the Hungarian Academy of Sciences and Department of Biophysics, Semmelweis University, Budapest, Hungary. ^[5] Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria. ^[6] Department of Surgery, Division of Thoracic Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria. ^[7] Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary. ^[8] Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. ^[9] Department of Thoracic Surgery, Ruhrlandklinik, University Clinic Essen, Essen, Germany. ^[10] Molecular Oncology Research Group of the Hungarian Academy of Sciences and 2nd Department of Pathology, Semmelweis University, Budapest, Hungary. ^[11]

关键词 BRAF mutant melanoma PMCA4b calcium signaling metastasis migration