首页> International journal of pharmaceutics> Impact of sodium chloride on the expansion of a liquid-liquid miscibility gap in an API/water system. Case study of Brivaracetam.

Impact of sodium chloride on the expansion of a liquid-liquid miscibility gap in an API/water system. Case study of Brivaracetam.

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第一作者： Nicolas,Couvrat

第一单位： Normandie Université, Laboratoire SMS-EA3233, Univ Rouen, F-76821 Mont Saint Aignan, France. Electronic address: nicolas.couvrat@univ-rouen.fr.

作者： Nicolas,Couvrat ^[1] ; Julien,Mahieux ^[2] ; Baptiste,Fours ^[3] ; Yohann,Cartigny ^[4] ; Eric,Schenkel ^[5] ; Luc,Aerts ^[6] ; Luc,Quéré ^[7] ; Gérard,Coquerel ^[8]

作者单位： Normandie Université, Laboratoire SMS-EA3233, Univ Rouen, F-76821 Mont Saint Aignan, France. Electronic address: nicolas.couvrat@univ-rouen.fr. ^[1] Nestec SA research center Nestlé, Route du Jorat 57, 1000, Lausanne 26, Switzerland. Electronic address: julien.mahieux@rdls.nestle.com. ^[2] Minakem Recherche, 145, Chemin des Lilas, F-59310 Beuvry-la-Forêt, France. Electronic address: baptiste.fours@minakem.com. ^[3] Normandie Université, Laboratoire SMS-EA3233, Univ Rouen, F-76821 Mont Saint Aignan, France. Electronic address: yohann.cartigny@univ-rouen.fr. ^[4] UCB Pharma S.A., Chemin du Foriest, B - 1420 Braine-l'Alleud, Belgium. Electronic address: eric.schenkel@ucb.com. ^[5] UCB Pharma S.A., Chemin du Foriest, B - 1420 Braine-l'Alleud, Belgium. Electronic address: luc.aerts@ucb.com. ^[6] UCB Pharma S.A., Chemin du Foriest, B - 1420 Braine-l'Alleud, Belgium. Electronic address: luc.quere@ucb.com. ^[7] Normandie Université, Laboratoire SMS-EA3233, Univ Rouen, F-76821 Mont Saint Aignan, France. Electronic address: gerard.coquerel@univ-rouen.fr. ^[8]

关键词 Brivaracetam Brivaracetam (PubChem CID: 9837243)IV administration Liquid-liquid miscibility gap Monotectic invariant Phase diagrams Tyndall effect

医学主题词投药, 膀胱内(Administration, Intravesical);吡咯烷酮类(Pyrrolidinones);氯化钠(Sodium Chloride);溶液(Solutions);水(Water)

DOI 10.1016/j.ijpharm.2016.11.003

PMID 27818243

发布时间 2017-08-28

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