首页> European journal of medicinal chemistry> Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

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第一作者： Fabien,Plisson

第一单位： Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.

作者： Fabien,Plisson ^[1] ; Timothy A,Hill ^[2] ; Justin M,Mitchell ^[1] ; Huy N,Hoang ^[1] ; Aline D,de Araujo ^[1] ; Weijun,Xu ^[1] ; Adam,Cotterell ^[1] ; David J,Edmonds ^[3] ; Robert V,Stanton ^[3] ; David R,Derksen ^[4] ; Paula M,Loria ^[4] ; David A,Griffith ^[3] ; David A,Price ^[3] ; Spiros,Liras ^[3] ; David P,Fairlie ^[5]

作者单位： Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. ^[1] Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: t.hill@imb.uq.edu.au. ^[2] Worldwide Medicinal Chemistry, Cardiovascular, Metabolic & Endocrine Diseases Research Unit, Pfizer Inc., Cambridge, MA 02140, United States. ^[3] Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, CT 06340, United States. ^[4] Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: d.fairlie@imb.uq.edu.au. ^[5]

关键词 Beta arrestin-2 Diabetes GLP-1 Insulin-release α-helix