Sequence variation at KLK and WFDC clusters and its association to semen hyperviscosity and other male infertility phenotypes.

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第一作者： Patrícia Isabel,Marques

第一单位： Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.;Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal.;Department of Biochemistry and Molecular Biology-IUOPA, University of Oviedo, 33006 Oviedo, Spain.;Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

作者： Patrícia Isabel,Marques ^[1] ; Filipa,Fonseca ^[2] ; Ana Sofia,Carvalho ^[3] ; Diana A,Puente ^[4] ; Isabel,Damião ^[5] ; Vasco,Almeida ^[6] ; Nuno,Barros ^[7] ; Alberto,Barros ^[8] ; Filipa,Carvalho ^[9] ; Mikel,Azkargorta ^[10] ; Felix,Elortza ^[10] ; Hugo,Osório ^[11] ; Rune,Matthiesen ^[3] ; Victor,Quesada ^[4] ; Susana,Seixas ^[12]

作者单位： Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.;Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal.;Department of Biochemistry and Molecular Biology-IUOPA, University of Oviedo, 33006 Oviedo, Spain.;Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal. ^[1] Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.;Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal. ^[2] Human Genetics Department, National Institute of Health Dr Ricardo Jorge (INSA), 1649-016 Lisboa, Portugal. ^[3] Department of Biochemistry and Molecular Biology-IUOPA, University of Oviedo, 33006 Oviedo, Spain. ^[4] Center of Infertility and Sterility Studies (CEIE), 4050-345 Porto, Portugal. ^[5] Center of Infertility and Sterility Studies (CEIE), 4050-345 Porto, Portugal.;Department of Biology, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal. ^[6] Center for Reproductive Genetics Alberto Barros, 4100-009 Porto, Portugal. ^[7] Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.;Center for Reproductive Genetics Alberto Barros, 4100-009 Porto, Portugal.;Department of Genetics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal. ^[8] Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.;Department of Genetics, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal. ^[9] Proteomics Platform CICbioGUNE, CIBERehd, ProteoRed-ISCIII, Parque Tecnologico de Bizkaia, Derio, Spain. ^[10] Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal.;Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal.;Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal. ^[11] Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), 4200-135 Porto, Portugal sseixas@ipatimup.pt.;Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal. ^[12]

关键词 genetic susceptibility prostate-specific antigen rare variants semen coagulation and liquefaction semenogelins