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首页> Journal of molecular and cellular cardiology> Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury.

Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury.

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作者： Weibing,Dong ^[1] ; Meiyi,Zhou ^[1] ; Mei,Dong ^[2] ; Bangfen,Pan ^[1] ; Yunxia,Liu ^[1] ; Jing,Shao ^[1] ; Xiaoping,Gu ^[1] ; Ying,Huang ^[1] ; Guangping,Li ^[2] ; Yibin,Wang ^[1] ; Haipeng,Sun ^[3]

作者单位： Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[1] Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China. ^[2] Division of Molecular Medicine, Departments of Anesthesiology, Medicine and Physiology, Molecular Biology Institute, Cardiovascular Research Laboratories, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA. ^[3]

关键词 Branched-chain amino acids Branched-chain keto acids Cell death Mitochondria Myocardial infarction Necrosis

主题词氨基酸类, 支链(Amino Acids, Branched-Chain);动物(Animals);细胞死亡(Cell Death);细胞系(Cell Line);细胞呼吸(Cell Respiration);疾病模型, 动物(Disease Models, Animal);能量代谢(Energy Metabolism);人类(Humans);酮酸类(Keto Acids);小鼠(Mice);线粒体(Mitochondria);心肌再灌注损伤(Myocardial Reperfusion Injury);肌细胞, 心脏(Myocytes, Cardiac);坏死(Necrosis);氧化性应激(Oxidative Stress)

DOI 10.1016/j.yjmcc.2016.11.002

PMID 27832938

发布时间 2018-11-13

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Journal of molecular and cellular cardiology

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