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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

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第一作者： Bruce A,Dressman

第一单位： Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA. Electronic address: DRESSMAN_BRUCE_A@lilly.com.

作者： Bruce A,Dressman ^[1] ; Eric G,Tromiczak ^[2] ; Mark D,Chappell ^[2] ; Allie E,Tripp ^[2] ; Steven J,Quimby ^[2] ; Tatiana,Vetman ^[2] ; Adam M,Fivush ^[2] ; James,Matt ^[2] ; Carlos,Jaramillo ^[3] ; Renhua,Li ^[2] ; Albert,Khilevich ^[2] ; Maria-Jesus,Blanco ^[2] ; Stephon C,Smith ^[2] ; Mercedes,Carpintero ^[3] ; José Eugenio,de Diego ^[3] ; Mario,Barberis ^[3] ; Susana,García-Cerrada ^[3] ; José F,Soriano ^[3] ; Jeffrey M,Schkeryantz ^[2] ; Jeffrey M,Witkin ^[2] ; Keith A,Wafford ^[4] ; Wesley,Seidel ^[4] ; Thomas,Britton ^[2] ; Carl D,Overshiner ^[2] ; Xia,Li ^[2] ; Xu-Shan,Wang ^[2] ; Beverly A,Heinz ^[2] ; John T,Catlow ^[2] ; Steven,Swanson ^[2] ; David,Bedwell ^[2] ; Paul L,Ornstein ^[2] ; Charles H,Mitch ^[2]

作者单位： Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA. Electronic address: DRESSMAN_BRUCE_A@lilly.com. ^[1] Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA. ^[2] Avenida de la Industria, 30, 28108 Alcobendas, Madrid, Spain. ^[3] Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK. ^[4]

关键词 Antidepressant Major depressive disorders Metabotropic glutamate mGlu(2/3) antagonist