Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?
作者:
主题词
抗肿瘤药(Antineoplastic Agents);结合部位(Binding Sites);量热法, 差式扫描(Calorimetry, Differential Scanning);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);圆二色性(Circular Dichroism);DNA, 肿瘤(DNA, Neoplasm);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物设计(Drug Design);G四链体(G-Quadruplexes);鸟苷(Guanosine);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);配体(Ligands);磁共振波谱学(Magnetic Resonance Spectroscopy);骨肉瘤(Osteosarcoma);构效关系(Structure-Activity Relationship);时间因素(Time Factors)
DOI
10.1016/j.bbagen.2016.11.008
PMID
27836755
发布时间
2018-09-17
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Biochimica et biophysica acta. General subjects
2017年1861卷5 Pt B期
1271-1280页
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