A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A<sup>y</sup> mice.
第一作者:
Kai,Wang
第一单位:
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No.1 Beichenxi Road, Chaoyang District, Beijing 100101, PR China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
作者:
医学主题词
脂肪组织(Adipose Tissue);丙氨酸转氨酶(Alanine Transaminase);动物(Animals);天冬氨酸氨基转移酶类(Aspartate Aminotransferases);血糖(Blood Glucose);体重(Body Weight);女(雌)性(Female);灵芝属(Ganoderma);糖原(Glycogen);氢醌类(Hydroquinones);羟甲基戊二酰基CoA还原酶抑制剂(Hydroxymethylglutaryl-CoA Reductase Inhibitors);降血糖药(Hypoglycemic Agents);胰岛素抗药性(Insulin Resistance);动力学(Kinetics);肝(Liver);男(雄)性(Male);小鼠(Mice);蛋白质构象(Protein Conformation);α葡糖苷酶类(alpha-Glucosidases)
DOI
10.1016/j.ejmech.2016.11.015
PMID
27839787
发布时间
2018-01-12
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European journal of medicinal chemistry
1035-1046页
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