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Cardioprotection and lifespan extension by the natural polyamine spermidine.

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作者单位: Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria. [1] BioTechMed Graz, Graz, Austria. [2] Department of Cardiology, Medical University of Graz, Graz, Austria. [3] Department of Internal Medicine and Cardiology, Campus Virchow-Klinikum, Charité-University Medicine Berlin, Berlin, Germany. [4] Department of Internal Medicine, Medical University of Graz, Graz, Austria. [5] Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. [6] Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany. [7] Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, USA. [8] Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria. [9] Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. [10] FRIAS Freiburg Institute for Advanced Studies, Department of Dermatology, Medical Center, ZBSA Center for Biological Systems Analysis, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany. [11] Department of Biology, University of Fribourg, Fribourg, Switzerland. [12] Clinical division of Nephrology, Medical University of Graz, Graz, Austria. [13] Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. [14] Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France. [15] Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France. [16] INSERM, U1138, Paris, France. [17] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [18] Université Pierre et Marie Curie, Paris, France. [19] Department of Biology, University of Padua, Padua, Italy. [20] Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padua, Italy. [21] Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, UK. [22] German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [23] Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Freising, Germany. [24] German Center for Diabetes Research (DZD), Neuherberg, Germany. [25] Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [26] Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians University München, Munich, Germany. [27] King's British Heart Foundation Centre, King's College London, London, UK. [28] Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. [29] Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [30] Department of Cardiovascular Physiology, Ruhr University Bochum, Bochum, Germany. [31] Department of Internal Medicine and Cardiology, German Heart Center Berlin, Berlin, Germany. [32] Institute for Biology, Freie Universität Berlin, Berlin, Germany. [33] NeuroCure, Charité, Berlin, Germany. [34] Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France. [35] Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden. [36]
DOI 10.1038/nm.4222
PMID 27841876
发布时间 2023-10-31
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