Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.

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作者： Kazuya,Sakata ^[1] ; Kimi,Araki ^[2] ; Hiroyasu,Nakano ^[1] ; Takashi,Nishina ^[3] ; Sachiko,Komazawa-Sakon ^[3] ; Shin,Murai ^[3] ; Grace E,Lee ^[3] ; Daisuke,Hashimoto ^[4] ; Chigure,Suzuki ^[2] ; Yasuo,Uchiyama ^[5] ; Kenji,Notohara ^[5] ; Anna S,Gukovskaya ^[6] ; Ilya,Gukovsky ^[4] ; Ken-Ichi,Yamamura ^[4] ; Hideo,Baba ^[1] ; Masaki,Ohmuraya ^[2]

作者单位： Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan. ^[1] Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan. ^[2] Department of Biochemistry, Toho University School of Medicine, 5-21-16 Omori-Nishi, Ota-ku, Tokyo 143-8540, Japan. ^[3] Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA. ^[4] Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. ^[5] Department of Pathology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama 710-8602, Japan. ^[6]

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);基因敲入技术(Gene Knock-In Techniques);糖蛋白类(Glycoproteins);人类(Humans);整合酶类(Integrases);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);胰腺炎(Pancreatitis);前列腺分泌蛋白质类(Prostatic Secretory Proteins);胰蛋白酶抑制剂, Kazal胰腺(Trypsin Inhibitor, Kazal Pancreatic);X染色体(X Chromosome)

DOI 10.1038/srep37200

PMID 27845447

发布时间 2018-11-13

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Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.

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Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome.

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