The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.

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作者： Hongmei,Liu ^[1] ; Xiaoling,Li ^[1] ; Guozhu,Ning ^[1] ; Shu,Zhu ^[1] ; Xiaolu,Ma ^[2] ; Xiuli,Liu ^[1] ; Chunying,Liu ^[3] ; Min,Huang ^[2] ; Ina,Schmitt ^[4] ; Ullrich,Wüllner ^[4] ; Yamei,Niu ^[3] ; Caixia,Guo ^[2] ; Qiang,Wang ^[1] ; Tie-Shan,Tang ^[1]

作者单位： State Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China. ^[1] CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China. ^[2] Department of Pathology and Center for Experimental Animal Research, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. ^[3] University of Bonn, Department of Neurology and German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. ^[4]

主题词动物(Animals);细胞凋亡(Apoptosis);Machado-Joseph病(Machado-Joseph Disease);小鼠(Mice);蛋白质稳定性(Protein Stability);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1371/journal.pbio.2000733

PMID 27851749

发布时间 2018-11-13

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