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Safety, Tolerability, and Pharmacokinetics of Liposomal Amphotericin B in Immunocompromised Pediatric Patients.

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第一作者： Nita L,Seibel

第一单位： Children's National Medical Center and George Washington University School of Medicine and Public Health, Washington, DC, USA.;Clinical Investigations Branch, Cancer Treatment Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.

作者： Nita L,Seibel ^[1] ; Aziza T,Shad ^[2] ; Ihor,Bekersky ^[3] ; Andreas H,Groll ^[4] ; Corina,Gonzalez ^[2] ; Lauren V,Wood ^[5] ; Paul,Jarosinski ^[6] ; Donald,Buell ^[3] ; William W,Hope ^[7] ; Thomas J,Walsh ^[8]

作者单位： Children's National Medical Center and George Washington University School of Medicine and Public Health, Washington, DC, USA.;Clinical Investigations Branch, Cancer Treatment Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA. ^[1] Department of Pediatrics, Division of Pediatric Hematology/Oncology, MedStar Georgetown University Hospital, Washington, DC, USA. ^[2] Astellas Pharma USA, Inc., Deerfield, Illinois, USA. ^[3] Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA.;Department of Pediatric Hematology and Oncology, University Children's Hospital, Münster, Germany. ^[4] Vaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. ^[5] Pharmacy Department, The NIH Clinical Center, Bethesda, Maryland, USA. ^[6] Antimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom. ^[7] Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA thw2003@med.cornell.edu.;Transplantation-Oncology Infectious Disease Program, Weill Cornell Medicine, New York City, New York, USA.;Department of Pediatrics, Weill Cornell Medicine, New York City, New York, USA.;Department of Microbiology and Immunology, Weill Cornell Medicine, New York City, New York, USA. ^[8]

关键词 antimicrobial safety and tolerability hematological malignancies liposomal amphotericin B pediatrics pharmacokinetics