Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex.

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第一作者： Okio,Hino

第一单位： Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan.

作者： Okio,Hino ^[1] ; Toshiyuki,Kobayashi ^[2]

作者单位： Department of Pathology and Oncology, Juntendo University Faculty of Medicine, Tokyo, Japan. ^[1] Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, Tokyo, Japan. ^[2]

关键词 Eker rat retinoblastoma tuberous sclerosis complex tumor suppressor gene two-hit hypothesis

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);黑腹果蝇(Drosophila melanogaster);基因, 肿瘤抑制(Genes, Tumor Suppressor);人类(Humans);模型, 遗传学(Models, Genetic);多蛋白复合物(Multiprotein Complexes);器官特异性(Organ Specificity);多潜能干细胞(Pluripotent Stem Cells);大鼠(Rats);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);结节性硬化症(Tuberous Sclerosis);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)

DOI 10.1111/cas.13116

PMID 27862655

发布时间 2021-12-04

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Cancer science

2017年108卷1期

5-11页

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Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex.

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Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex.

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