A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.

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作者： Mahesh S,Desai ^[1] ; Anna M,Seekatz ^[2] ; Nicole M,Koropatkin ^[2] ; Nobuhiko,Kamada ^[2] ; Christina A,Hickey ^[3] ; Mathis,Wolter ^[4] ; Nicholas A,Pudlo ^[2] ; Sho,Kitamoto ^[2] ; Nicolas,Terrapon ^[5] ; Arnaud,Muller ^[6] ; Vincent B,Young ^[2] ; Bernard,Henrissat ^[5] ; Paul,Wilmes ^[7] ; Thaddeus S,Stappenbeck ^[3] ; Gabriel,Núñez ^[2] ; Eric C,Martens ^[8]

作者单位： Luxembourg Centre for Systems Biomedicine, Esch-sur-Alzette 4362, Luxembourg; University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette 4354, Luxembourg. Electronic address: mahesh.desai@lih.lu. ^[1] University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[2] Washington University School of Medicine, St. Louis, MO 63110, USA. ^[3] Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette 4354, Luxembourg. ^[4] Aix-Marseille Université, UMR 7257, 13288 Marseille, France. ^[5] Department of Oncology, Luxembourg Institute of Health, Luxembourg 1526, Luxembourg. ^[6] Luxembourg Centre for Systems Biomedicine, Esch-sur-Alzette 4362, Luxembourg. ^[7] University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: emartens@umich.edu. ^[8]

关键词 Akkermansia Citrobacter rodentium bacteroides dietary fiber gylcans microbiome microbiota mucin mucus layer polysaccharides