β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance.

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作者： Boris,Novakovic ^[1] ; Ehsan,Habibi ^[1] ; Shuang-Yin,Wang ^[1] ; Rob J W,Arts ^[2] ; Robab,Davar ^[1] ; Wout,Megchelenbrink ^[1] ; Bowon,Kim ^[1] ; Tatyana,Kuznetsova ^[1] ; Matthijs,Kox ^[3] ; Jelle,Zwaag ^[3] ; Filomena,Matarese ^[1] ; Simon J,van Heeringen ^[4] ; Eva M,Janssen-Megens ^[1] ; Nilofar,Sharifi ^[1] ; Cheng,Wang ^[1] ; Farid,Keramati ^[1] ; Vivien,Schoonenberg ^[1] ; Paul,Flicek ^[5] ; Laura,Clarke ^[5] ; Peter,Pickkers ^[3] ; Simon,Heath ^[6] ; Ivo,Gut ^[6] ; Mihai G,Netea ^[2] ; Joost H A,Martens ^[1] ; Colin,Logie ^[1] ; Hendrik G,Stunnenberg ^[7]

作者单位： Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. ^[1] Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases (RCI), 6525 GA Nijmegen, the Netherlands. ^[2] Department of Intensive Care Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases (RCI), 6500 HB Nijmegen, the Netherlands. ^[3] Department of Molecular Developmental Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. ^[4] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK. ^[5] Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona, 08028 Barcelona, Spain. ^[6] Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. Electronic address: h.stunnenberg@ncmls.ru.nl. ^[7]

关键词 BLUEPRINT endotoxin tolerance epigenome histone modifications human monocytes lipopolysaccharide macrophages trained innate immunity transcriptome β-glucan