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Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression.

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第一作者： Rémy,Denzler

第一单位： Institute of Molecular Health Sciences, Swiss Federal Institute of Technology in Zurich (ETH Zurich), Otto-Stern-Weg 7, 8093 Zürich, Switzerland.

作者： Rémy,Denzler ^[1] ; Sean E,McGeary ^[2] ; Alexandra C,Title ^[1] ; Vikram,Agarwal ^[3] ; David P,Bartel ^[4] ; Markus,Stoffel ^[5]

作者单位： Institute of Molecular Health Sciences, Swiss Federal Institute of Technology in Zurich (ETH Zurich), Otto-Stern-Weg 7, 8093 Zürich, Switzerland. ^[1] Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[2] Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. ^[3] Howard Hughes Medical Institute, Cambridge, MA 02142, USA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: dbartel@wi.mit.edu. ^[4] Institute of Molecular Health Sciences, Swiss Federal Institute of Technology in Zurich (ETH Zurich), Otto-Stern-Weg 7, 8093 Zürich, Switzerland. Electronic address: stoffel@biol.ethz.ch. ^[5]

关键词 base pair complementarity competing endogenous RNA cooperatively gene regulation miRNA miRNA degradation target abundance