换一批pH-Sensitive PEGylated liposomes for delivery of an acidic dinitrobenzamide mustard prodrug: Pathways of internalization, cellular trafficking and cytotoxicity to cancer cells.
第一作者：
Mimi M,Yang
第一单位：
School of Pharmacy, The University of Auckland, Auckland 1142, New Zealand.
作者：
关键词
(CID 406952)(CID 44134771)(CID 5997)1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[Methoxy(Polyethylene glycol)-2000]1,2-dioleoy-sn-glycero-3-phosphoethanolamine1,2-distearoyl-sn-glycero-3-phosphocholineActive loadingCHEMS (CID 65082)CholesterolCholesteryl hemisuccinateDOPE (CID 9546744)DSPC (CID 94190)Endosome escapeGene-directed enzyme-prodrug therapyHydroxypropyl-β-cyclodextrinpH-sensitive liposomes
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);苯甲酰胺类(Benzamides);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);色谱法, 高压液相(Chromatography, High Pressure Liquid);药物释放系统(Drug Delivery Systems);内颗粒(Endosomes);女(雌)性(Female);流式细胞术(Flow Cytometry);氢离子浓度(Hydrogen-Ion Concentration);脂质体(Liposomes);乳房肿瘤, 动物(Mammary Neoplasms, Animal);小鼠(Mice);显微镜检查, 共焦(Microscopy, Confocal);氮芥化合物(Nitrogen Mustard Compounds);聚乙烯二醇类(Polyethylene Glycols);药物前体(Prodrugs);溶解度(Solubility);转染(Transfection)
DOI
10.1016/j.ijpharm.2016.11.041
PMID
27871834
发布时间
2018-12-02
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