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High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis.

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作者单位: Center for Molecular Medicine at Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. [1] Department of Medicine, Unit of Computational Medicine, Stockholm, Sweden. [2] Bioinformatic Infrastructure for Life Sciences, Stockholm, Sweden. [3] Mucosal and Salivary Biology Division, King's College London Dental Institute, London, UK. [4] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. [5] Center for Epigenetics, Johns Hopkins University, Baltimore, MD, USA. [6] Department of Medicine, Unit of Rheumatology, Karolinska University Hospital Solna, Stockholm, Sweden. [7] Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden. [8] Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden. [9] Translational Immunology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. [10] Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. [11] Medical Scientist Training Program, and Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. [12] Departments of Pathology, Massachusetts General Hospital, Charlestown, MA, USA. [13] Harvard Medical School, Boston, MD, USA. [14] Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA. [15] Broad Institute of Harvard and MIT, Cambridge, MA, USA. [16] Departments of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. [17] Departments of Biostatistics, Johns Hopkins University, Baltimore, MD, USA. [18] Center for Molecular Medicine at Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Tomas.Ekstrom@ki.se. [19] Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Tomas.Ekstrom@ki.se. [20]
DOI 10.1186/s13073-016-0374-0
PMID 27876072
发布时间 2018-11-13
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