NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.-论文-万方医学网

第一作者： Yanke,Zhang

第一单位： Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, 1 Youyi Road, Chongqing 400016, China.

作者： Yanke,Zhang ^[1] ; Guojun,Chen ^[1] ; Baobing,Gao ^[2] ; Yunlin,Li ^[3] ; Shuli,Liang ^[4] ; Xiaofei,Wang ^[5] ; Xuefeng,Wang ^[6] ; Binglin,Zhu ^[1]

作者单位： Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, 1 Youyi Road, Chongqing 400016, China. ^[1] Department of Neurology, Chongqing General Hospital, 104 Pipashan Street, Chongqing 400010, China. ^[2] Department of Neurosurgery, The Affiliated Children's Hospital of Capital Institute of Pediatrics, 2 Yabao Road, Beijing 100020, China. ^[3] Department of Neurosurgery, The First Affiliated Hospital of PLA General Hospital, 51 Fucheng Road, Beijing 100048, China. ^[4] Department of Neurology, The Affiliated Children's Hospital, Capital Medical University, 56 Nanlishi Road, Xicheng District, Beijing 100032, China. ^[5] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, 1 Youyi Road, Chongqing 400016, China.;Center of Epilepsy, Beijing Institute for Brain Disorders, 10 Xitoutiao, Youanmen, Fengtai District, Beijing 100069, China. ^[6]

医学主题词青少年(Adolescent);成年人(Adult);动物(Animals);行为, 动物(Behavior, Animal);病例对照研究(Case-Control Studies);儿童(Child);疾病模型, 动物(Disease Models, Animal);减量调节(Down-Regulation);女(雌)性(Female);基因敲低技术(Gene Knockdown Techniques);绿色荧光蛋白质类(Green Fluorescent Proteins);海马(Hippocampus);人类(Humans);慢病毒属(Lentivirus);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);中年人(Middle Aged);新皮质(Neocortex);核受体亚家族4, A组, 成员1(Nuclear Receptor Subfamily 4, Group A, Member 1);毛果芸香碱(Pilocarpine);RNA, 小分子干扰(RNA, Small Interfering);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);发作(Seizures);突触(Synapses);青年人(Young Adult)

DOI 10.1038/srep37713

PMID 27876882

发布时间 2018-11-13

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NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.

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NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.

Scientific reports

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Scientific reports

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