A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade.

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作者： Raghu,Ningegowda ^[1] ; Nanjunda Swamy,Shivananju ^[2] ; Peramiyan,Rajendran ^[3] ; Basappa ^[4] ; Kanchugarakoppal S,Rangappa ^[5] ; Arunachalam,Chinnathambi ^[6] ; Feng,Li ^[3] ; Raghu Ram,Achar ^[2] ; Muthu K,Shanmugam ^[3] ; Pradeep,Bist ^[7] ; Sulaiman Ali,Alharbi ^[6] ; Lina Hsiu Kim,Lim ^[7] ; Gautam,Sethi ^[8] ; Babu Shubha,Priya ^[9]

作者单位： Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, Karnataka, India. ^[1] Department of Biotechnology, JSS Science and Technology University, JSS Technical Institutions Campus, Mysore, 570006, Karnataka, India. ^[2] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. ^[3] Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Central College Campus, Palace Road, Bangalore, 560001, Karnataka, India. ^[4] Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India. ^[5] Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. ^[6] Department of Physiology, Centre for Life Sciences, NUHS, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore. ^[7] Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. phcgs@nus.edu.sg. ^[8] Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, Karnataka, India. priyabs_chem@yahoo.com. ^[9]

关键词 Apoptosis Invasion NF-kB TNFa Thiadiazole