CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.

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作者： Yanyan,Zhang ^[1] ; Mallorie,Dépond ^[1] ; Liang,He ^[1] ; Adlen,Foudi ^[2] ; Edward Owusu,Kwarteng ^[1] ; Evelyne,Lauret ^[3] ; Isabelle,Plo ^[1] ; Christophe,Desterke ^[4] ; Philippe,Dessen ^[5] ; Nobutaka,Fujii ^[6] ; Paule,Opolon ^[7] ; Olivier,Herault ^[8] ; Eric,Solary ^[9] ; William,Vainchenker ^[1] ; Virginie,Joulin ^[1] ; Fawzia,Louache ^[1] ; Monika,Wittner ^[1]

作者单位： Paris-Saclay University, UMRS-1170, Gustave Roussy, Villejuif, France. ^[1] Paris-Saclay University, INSERM U935, Andre Lwoff Institute, Paul Brousse Hospital, Villejuif, France. ^[2] Paris Descartes University, CNRS (UMR 8104), Inserm U1016, Institut Cochin, Paris, France. ^[3] Paris-Saclay University, UFR Medicine, INSERM UMS 33, Andre Lwoff Institute, Paul Brousse Hospital, Villejuif, France. ^[4] Bioinformatic platform, UMS AMMICA, INSERM US23/CNRS UMS3665, Gustave Roussy, Villejuif, France. ^[5] Kyoto University, Graduate School of Pharmaceutical Sciences, Kyoto, Japan. ^[6] Laboratoire de pathologie expérimentale, Gustave Roussy, Villejuif, France. ^[7] CNRS UMR 7292 GICC, Tours, France. ^[8] CNRS GDR 3697 MicroNiT, France. ^[9]

主题词动物(Animals);细胞分化(Cell Differentiation);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);趋化因子CXCL12(Chemokine CXCL12);DNA断裂, 双链(DNA Breaks, Double-Stranded);造血干细胞移植(Hematopoietic Stem Cell Transplantation);造血干细胞(Hematopoietic Stem Cells);肝细胞(Hepatocytes);小鼠(Mice);线粒体(Mitochondria);氧化性应激(Oxidative Stress);磷酰化(Phosphorylation);活性氧(Reactive Oxygen Species);受体, CXCR4(Receptors, CXCR4);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1038/srep37827

PMID 27886253

发布时间 2022-04-10

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CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.

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CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.

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