Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives.

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作者： Uzma,Salar ^[1] ; Khalid Mohammed,Khan ^[2] ; Muhammad,Taha ^[3] ; Nor Hadiani,Ismail ^[4] ; Basharat,Ali ^[1] ; Qurat-Ul-Ain ^[1] ; Shahnaz,Perveen ^[5] ; Mehreen,Ghufran ^[6] ; Abdul,Wadood ^[6]

作者单位： H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. ^[1] H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. Electronic address: khalid.khan@iccs.edu. ^[2] Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor D. E., Malaysia; Faculty of Applied Science, Universiti Teknologi MARA, Shah Alam, 40450, Selangor D. E., Malaysia. ^[3] Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300, Bandar Puncak Alam, Selangor D. E., Malaysia. ^[4] PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, 75280, Pakistan. ^[5] Department of Biochemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan. ^[6]

关键词 In silico In?vitro Structure-activity relationship Synthesis β-Glucuronidase