ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.

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作者： Praveen K,Sobhan ^[1] ; Qiwei,Zhai ^[2] ; Lydia C,Green ^[3] ; Loen M,Hansford ^[4] ; Keiko,Funa ^[5]

作者单位： Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden. Electronic address: kspraveen01@gmail.com. ^[1] Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden. Electronic address: qiwei.zhai@gu.se. ^[2] Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden. Electronic address: lydia.green@gu.se. ^[3] Program in Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto, Toronto, Canada. Electronic address: loen.hansford@gmail.com. ^[4] Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden; Oncology Laboratory, Department of Pathology, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden. Electronic address: keiko.funa@gu.se. ^[5]

关键词 ASK1 Apoptosis HIF-1α Neuroblastoma TLX

主题词动物(Animals);细胞凋亡(Apoptosis);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);苯咪唑类(Benzimidazoles);羰花青(Carbocyanines);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);基因沉默(Gene Silencing);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);MAP激酶激酶激酶5(MAP Kinase Kinase Kinase 5);膜电位, 线粒体(Membrane Potential, Mitochondrial);小鼠, SCID(Mice, SCID);神经母细胞瘤(Neuroblastoma);孤儿核受体(Orphan Nuclear Receptors);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);蛋白质稳定性(Protein Stability);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1016/j.cellsig.2016.11.018

PMID 27890558

发布时间 2021-12-04

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Cellular signalling

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ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.

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Cellular signalling

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ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1α.

Cellular signalling

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Cellular signalling

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