Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.

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作者： Robert,Gustafsson ^[1] ; Ann-Sofie,Jemth ^[2] ; Nina M S,Gustafsson ^[2] ; Katarina,Färnegårdh ^[3] ; Olga,Loseva ^[2] ; Elisée,Wiita ^[2] ; Nadilly,Bonagas ^[2] ; Leif,Dahllund ^[4] ; Sabin,Llona-Minguez ^[2] ; Maria,Häggblad ^[5] ; Martin,Henriksson ^[2] ; Yasmin,Andersson ^[4] ; Evert,Homan ^[2] ; Thomas,Helleday ^[6] ; Pål,Stenmark ^[7]

作者单位： Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. ^[1] Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. ^[2] Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University, Solna, Sweden. ^[3] Drug Discovery and Development Platform, Science for Life Laboratory, School of Biotechnology, Royal Institute of Technology, Solna, Sweden. ^[4] Biochemical and Cellular Screening, Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. ^[5] Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. stenmark@dbb.su.se thomas.helleday@scilifelab.se. ^[6] Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. stenmark@dbb.su.se thomas.helleday@scilifelab.se. ^[7]