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Dietary fat and gut microbiota interactions determine diet-induced obesity in mice.

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第一作者: Raphaela,Kübeck
第一单位: ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan, EKFZ - Else Kröner-Fresenius-Center for Nutritional Medicine, Gregor-Mendel-Str. 2, 85354 Freising, Germany.
作者单位: ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan, EKFZ - Else Kröner-Fresenius-Center for Nutritional Medicine, Gregor-Mendel-Str. 2, 85354 Freising, Germany. [1] Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz Zentrum München, Ingolstädter Landstr.1, 85764 Neuherberg, Germany. [2] ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair of Nutritional Physiology, Technical University of Munich, TUM School of Life Sciences Weihenstephan, Gregor-Mendel-Str. 2, 85354 Freising, Germany. [3] ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair of Nutrition and Immunology, Technical University of Munich, TUM School of Life Sciences Weihenstephan, Maximus-von-Imhof-Forum 2, 85354 Freising, Germany. [4] ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany. [5] Chair of General Food Technology, Technische Universität München, Alte Akademie 10, 85354 Freising, Germany. [6] Chair of Nutritional Physiology, Technical University of Munich, TUM School of Life Sciences Weihenstephan, Gregor-Mendel-Str. 2, 85354 Freising, Germany. [7] ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Research Unit Analytical BioGeoChemistry, Department of Environmental Sciences, Helmholtz Zentrum München, Ingolstädter Landstr.1, 85764 Neuherberg, Germany; Chair of Analytical Food Chemistry, Technische Universität München, Alte Akademie 10, 85354 Freising, Germany. [8] ZIEL - Institute for Food and Health, Technical University of Munich, Gregor-Mendel-Str. 2, 85354 Freising, Germany; Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan, EKFZ - Else Kröner-Fresenius-Center for Nutritional Medicine, Gregor-Mendel-Str. 2, 85354 Freising, Germany. Electronic address: mk@tum.de. [9]
关键词 ANOVA, analysis of varianceAbcg5, ATP-binding cassette sub-family G member 5Abcg8, ATP-binding cassette sub-family G member 8Actb, beta actinAkr1d1, aldo-keto-reductase family member 1BMR, basal metabolic rateCA, cholic acidCD, control dietCDCA, chenodeoxycholic acidCIDEA, cell death inducing DFFA-like effectorCOX4, cytochrome c oxidase subunit 4Cyp27a1, cholesterol 27 alpha-hydroxylaseCyp7a1, cholesterol 7 alpha-hydroxylaseDCA, deoxycholic acidDEE, daily energy expenditureDIO, diet-induced obesityDhcr7, 7-dehydrocholesterol reductaseDiet-induced obesity resistanceEef2, eukaryotic elongation factor 2Energy balanceFT-ICR-MS, Fourier transform-Ion Cyclotron Resonance-Mass SpectrometryFT-IR, Fourier transform-infrared spectroscopyGF, germfreeGUSB, beta-glucuronidaseGermfreeHDCA, hyodeoxycholic acidHP, heat productionHigh-fat dietHmgcr, 3-hydroxy-3-methylglutaryl Coenzyme A reductaseHmgcs, 3-hydroxy-3-methylglutaryl Coenzyme A synthase 1Hprt1, hypoxanthine guanine phosphoribosyl transferaseHsd11b1, hydroxysteroid (11-β) dehydrogenase 1Hsp90, heat shock protein 90LHFD, high-fat diet based on lardLdlr, low density lipoprotein receptorMCA, muricholic acidNr1h2, nuclear receptor subfamily 1, group H, member 2 (liver X receptor β)Nr1h3, nuclear receptor subfamily 1, group H, member 3 (liver X receptor α)Nr1h4, nuclear receptor subfamily 1, group H, member 4 (farnesoid X receptor α)PHFD, high-fat diet based on palm oilPRDM16, PR domain containing 16SPF, specific pathogen freeSrebf1, sterol regulatory element binding transcription factor 1TCA, taurocholic acidTMCA, Tauromuricholic acidTf2b, transcription factor II BUCP1, uncoupling protein 1UDCA, ursodeoxycholic acidUPLC-TOF-MS, ultraperformance liquid chromatography-time of flight-mass spectrometryqPCR, quantitative real-time polymerase chain reaction
DOI 10.1016/j.molmet.2016.10.001
PMID 27900259
发布时间 2018-11-13
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Molecular metabolism

Molecular metabolism

2016年5卷12期

1162-1174页

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