Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats.

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作者： Naomi,Lomeli ^[1] ; Kaijun,Di ^[2] ; Jennifer,Czerniawski ^[3] ; John F,Guzowski ^[4] ; Daniela A,Bota ^[5]

作者单位： Department of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA. Electronic address: nrlomeli@uci.edu. ^[1] Department of Neurological Surgery, University of California Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA. Electronic address: kdi@uci.edu. ^[2] Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, USA; Center for the Neurobiology of Learning & Memory, University of California Irvine, Irvine, CA, USA. Electronic address: jczernia@uci.edu. ^[3] Department of Neurobiology & Behavior, University of California Irvine, Irvine, CA, USA; Center for the Neurobiology of Learning & Memory, University of California Irvine, Irvine, CA, USA. Electronic address: john.g@uci.edu. ^[4] Department of Pathology & Laboratory Medicine, University of California Irvine, Irvine, CA, USA; Department of Neurological Surgery, University of California Irvine, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA; Department of Neurology, University of California Irvine, Irvine, CA, USA. Electronic address: dbota@uci.edu. ^[5]

关键词 Chemotherapy Chemotherapy-related cognitive impairment (CRCI)Cisplatin (CDDP)DNA damage Hippocampal neurons Mitochondria N-acetylcysteine (NAC)Neural stem/precursor cells (NSCs)Oxidative stress