Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

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作者： Paul,Lebeau ^[1] ; Ali,Al-Hashimi ^[1] ; Sudesh,Sood ^[1] ; Šárka,Lhoták ^[1] ; Pei,Yu ^[2] ; Gabriel,Gyulay ^[3] ; Guillaume,Paré ^[1] ; S R Wayne,Chen ^[4] ; Bernardo,Trigatti ^[5] ; Annik,Prat ^[2] ; Nabil G,Seidah ^[3] ; Richard C,Austin ^[6]

作者单位： From the Department of Medicine, Division of Nephrology, McMaster University and St. Joseph's Hamilton Healthcare and Hamilton Centre for Kidney Research, Hamilton, Ontario L8N 4A6. ^[1] the Thrombosis and Atherosclerosis Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario L8L 2X2. ^[2] the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4L8. ^[3] the Population Health Research Institute and the Departments of Medicine, Epidemiology and Pathology, McMaster University, Hamilton, Ontario L8L 2X2. ^[4] the Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 2T9, and. ^[5] the Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, affiliated with the University of Montreal, Montreal, Quebec H2W 1R7, Canada. ^[6] From the Department of Medicine, Division of Nephrology, McMaster University and St. Joseph's Hamilton Healthcare and Hamilton Centre for Kidney Research, Hamilton, Ontario L8N 4A6, austinr@taari.ca. ^[7]

关键词 ER calcium SREBP2 cholesterol endoplasmic reticulum stress (ER stress)hepatocyte hepatocytes low density lipoprotein (LDL)proprotein convertase subtilisin/kexin type 9 (PCSK9)