ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

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作者： Taru,Muranen ^[1] ; Laura M,Selfors ^[1] ; Julie,Hwang ^[1] ; Lisa L,Gallegos ^[1] ; Jonathan L,Coloff ^[1] ; Carson C,Thoreen ^[2] ; Seong A,Kang ^[3] ; David M,Sabatini ^[4] ; Gordon B,Mills ^[5] ; Joan S,Brugge ^[2]

作者单位： Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts. ^[1] Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts. ^[2] Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts. ^[3] Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts. ^[4] Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts. ^[5] Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. ^[6] Department of Cell Biology and Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts. joan_brugge@hms.harvard.edu. ^[7]