Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease.

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第一作者： Sascha,Bruckmann

第一单位： Department of Neuropathology, Institute of Pathology, University Medicine Greifswald, Greifswald. Germany.

作者： Sascha,Bruckmann ^[1] ; Anja,Brenn ^[1] ; Markus,Grube ^[2] ; Katharina,Niedrig ^[3] ; Silva,Holtfreter ^[4] ; Oliver,von Bohlen und Halbach ^[3] ; Martin,Groschup ^[5] ; Markus,Keller ^[5] ; Silke,Vogelgesang ^[1]

作者单位： Department of Neuropathology, Institute of Pathology, University Medicine Greifswald, Greifswald. Germany. ^[1] Department of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Greifswald. Germany. ^[2] Institute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald. Germany. ^[3] Department of Immunology, University Medicine, Greifswald. Germany. ^[4] Friedrich-Loeffler-Institute, Institute for Novel and Emerging Infectious Diseases, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Greifswald. Germany. ^[5]

关键词 Active immunization Alzheimer's disease Pglycoprotein amyloid angiopathy beta-amyloid blood-brain-barrier clearance