The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.

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作者： Anne Cathrine,Nøhr ^[1] ; Mohamed A,Shehata ^[1] ; Alexander S,Hauser ^[1] ; Vignir,Isberg ^[1] ; Jacek,Mokrosinski ^[2] ; Kirsten B,Andersen ^[1] ; I Sadaf,Farooqi ^[2] ; Daniel Sejer,Pedersen ^[1] ; David E,Gloriam ^[3] ; Hans,Bräuner-Osborne ^[4]

作者单位： Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. ^[1] University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom. ^[2] Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: david.goriam@sund.ku.dk. ^[3] Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: hbo@sund.ku.dk. ^[4]

关键词 Adrenocorticotropic hormone (ACTH)GPR139 Melanocyte stimulating hormone (MSH)Orphan GPCR Peptide receptor Pro-opiomelanocortin (POMC)