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Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.

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第一作者： Yan,Li

第一单位： Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

作者： Yan,Li ^[1] ; Xiaoming,Qiang ^[1] ; Li,Luo ^[1] ; Xia,Yang ^[1] ; Ganyuan,Xiao ^[1] ; Yunxiaozhu,Zheng ^[1] ; Zhongcheng,Cao ^[1] ; Zhipei,Sang ^[2] ; Fu,Su ^[3] ; Yong,Deng ^[4]

作者单位： Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. ^[1] College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China. ^[2] Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: sufu@scu.edu.cn. ^[3] Department of Medicinal Chemistry, Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic address: dengyong@scu.edu.cn. ^[4]

关键词 Acetylcholinesterase inhibitors Alzheimer’s disease Homoisoflavonoid Mannich base derivatives Monoamine oxidase B inhibitors Multifunctional properties