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Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire.

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第一作者： Sandra,Ammann

第一单位： Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.;Faculty of Biology, University of Freiburg, Germany.

作者： Sandra,Ammann ^[1] ; Kai,Lehmberg ^[2] ; Udo,Zur Stadt ^[3] ; Gritta,Janka ^[2] ; Anne,Rensing-Ehl ^[4] ; Christian,Klemann ^[5] ; Maximilian,Heeg ^[5] ; Sebastian,Bode ^[5] ; Ilka,Fuchs ^[4] ; Stephan,Ehl ^[5] ; HLH study of the GPOH

作者单位： Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.;Faculty of Biology, University of Freiburg, Germany. ^[1] Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Germany. ^[2] Center for Diagnostic, University Medical Center Hamburg Eppendorf, Germany. ^[3] Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. ^[4] Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.;Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. ^[5]

关键词 HLA-DR Hemophagocytic lymphohistiocytosis Perforin Primary HLH Secondary HLH T-cell activation