Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.-论文-万方医学网

第一作者： Juan,Yang

第一单位： Key Laboratory of Stem Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai 200031, China.

作者： Juan,Yang ^[1] ; Hanzhi,Zhao ^[1] ; Yu,Ma ^[2] ; Guilai,Shi ^[1] ; Jian,Song ^[1] ; Yu,Tang ^[1] ; Song,Li ^[3] ; Ting,Li ^[1] ; Nan,Liu ^[4] ; Fan,Tang ^[2] ; Junjie,Gu ^[2] ; Lingling,Zhang ^[1] ; Zhuohua,Zhang ^[5] ; Xiaohui,Zhang ^[4] ; Ying,Jin ^[2] ; Weidong,Le ^[6]

作者单位： Key Laboratory of Stem Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai 200031, China. ^[1] Key Laboratory of Stem Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai 200031, China.;Shanghai Stem Cell Institute, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China. ^[2] Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China. ^[3] Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. ^[4] Institute of Precision Medicine, The Xiangya Hospital, State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University, Changsha 410078, China. ^[5] Key Laboratory of Stem Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai 200031, China.;Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China.;Institute of Neurology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.;Collaborative Innovation Center for Brain Science, the First Affiliated Hospital, Dalian Medical University, Dalian 116011, China. ^[6]

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);细胞凋亡(Apoptosis);细胞系(Cell Line);细胞增殖(Cell Proliferation);女(雌)性(Female);遗传标记(Genetic Markers);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);中年人(Middle Aged);突变(Mutation);神经干细胞(Neural Stem Cells);神经发生(Neurogenesis);肽碎片(Peptide Fragments);表型(Phenotype);磷酰化(Phosphorylation);早老素1(Presenilin-1);时间因素(Time Factors);tau蛋白质类(tau Proteins)

DOI 10.18632/oncotarget.13776

PMID 27926491

发布时间 2022-04-09

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Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.

Oncotarget

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Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.

Oncotarget

相似文献

同项目论文

Oncotarget

相关期刊

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