首页> The Journal of biological chemistry> Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.

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第一作者： Jude T,Chenge

第一单位： From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom.

作者： Jude T,Chenge ^[1] ; Le Van,Duyet ^[1] ; Shalini,Swami ^[1] ; Kirsty J,McLean ^[1] ; Madeline E,Kavanagh ^[2] ; Anthony G,Coyne ^[2] ; Stephen E J,Rigby ^[1] ; Myles R,Cheesman ^[3] ; Hazel M,Girvan ^[1] ; Colin W,Levy ^[1] ; Bernd,Rupp ^[4] ; Jens P,von Kries ^[4] ; Chris,Abell ^[2] ; David,Leys ^[1] ; Andrew W,Munro ^[5]

作者单位： From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom. ^[1] the Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. ^[2] the School of Chemistry, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom, and. ^[3] the Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Strasse 10, 13125 Berlin, Germany. ^[4] From the Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom, Andrew.Munro@Manchester.ac.uk. ^[5]

关键词 CYP126A1 Mycobacterium tuberculosis cytochrome P450 electron paramagnetic resonance (EPR)enzyme structure high throughput screening (HTS)mass spectrometry (MS)redox potentiometry

医学主题词抗真菌药(Antifungal Agents);细菌蛋白质类(Bacterial Proteins);催化域(Catalytic Domain);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);酮康唑(Ketoconazole);结核分枝杆菌(Mycobacterium tuberculosis);蛋白质结构, 二级(Protein Structure, Secondary)

DOI 10.1074/jbc.M116.748822

PMID 27932461

发布时间 2025-05-30

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