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NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus.

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第一作者： Elise S,Demitrack

第一单位： Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan.

作者： Elise S,Demitrack ^[1] ; Gail B,Gifford ^[1] ; Theresa M,Keeley ^[1] ; Nobukatsu,Horita ^[1] ; Andrea,Todisco ^[2] ; D Kim,Turgeon ^[2] ; Christian W,Siebel ^[3] ; Linda C,Samuelson ^[4]

作者单位： Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan. ^[1] Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan; and. ^[2] Department of Discovery Oncology, Genentech, Incorporated, San Francisco, California. ^[3] Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan; lcsam@umich.edu.;Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan; and. ^[4]

关键词 SOX2 cellular differentiation gastric organoids gastric stem cells spasmolytic polypeptide expressing metaplasia (SPEM)

医学主题词动物(Animals);细胞增殖(Cell Proliferation);上皮细胞(Epithelial Cells);女(雌)性(Female);胃黏膜(Gastric Mucosa);基因, 报告(Genes, Reporter);人类(Humans);男(雄)性(Male);小鼠(Mice);类器官(Organoids);受体, Notch1(Receptor, Notch1);受体, Notch2(Receptor, Notch2);信号传导(Signal Transduction);干细胞(Stem Cells);胃(Stomach);他莫昔芬(Tamoxifen)

DOI 10.1152/ajpgi.00325.2016

PMID 27932500

发布时间 2024-07-16

基金项目

P30 DK034933/DK/NIDDK NIH HHS/United States T32 GM008322/GM/NIGMS NIH HHS/United States T32 HD007505/HD/NICHD NIH HHS/United States UL1 TR000433/TR/NCATS NIH HHS/United States

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