Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.

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作者： Patrick R,Visperas ^[1] ; Christopher G,Wilson ^[2] ; Jonathan A,Winger ^[3] ; Qingrong,Yan ^[1] ; Kevin,Lin ^[4] ; Michelle R,Arkin ^[1] ; Arthur,Weiss ^[5] ; John,Kuriyan ^[1]

作者单位： 1 Department of Molecular and Cell Biology and Department of Chemistry, California Institute of Quantitative Biosciences and Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. ^[1] Plexxikon Inc., Berkeley, CA, USA. ^[2] 3 Department of Pharmaceutical Chemistry, Small Molecule Discovery Center, University of California, San Francisco, CA, USA. ^[3] Omniox Inc., San Carlos, CA, USA. ^[4] Janssen Pharmaceuticals Inc., Titusville, NJ, USA. ^[5] 4 Department of Medicine, Rosalind Russell and Ephrain P. Engleman Rheumatology Research Center for Arthritis and Howard Hughes Medical Institute, University of California, San Francisco, CA, USA. ^[6] 2 Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. ^[7]

关键词 T cell ZAP-70 covalent inhibitor fluorescence polarization (FP)kinase time-resolved fluorescence resonance energy transfer (TR-FRET)

主题词无细胞系统(Cell-Free System);荧光偏振(Fluorescence Polarization);荧光共振能量转移(Fluorescence Resonance Energy Transfer);基因表达(Gene Expression);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);免疫因子类(Immunologic Factors);肽类(Peptides);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);重组蛋白质类(Recombinant Proteins);信号传导(Signal Transduction);小分子化合物库(Small Molecule Libraries);ZAP-70蛋白酪氨酸激酶(ZAP-70 Protein-Tyrosine Kinase)

DOI 10.1177/1087057116681407

PMID 27932698

发布时间 2022-08-30

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SLAS discovery

2017年22卷3期

324-331页

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Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.

SLAS discovery

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SLAS discovery

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Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.

SLAS discovery

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SLAS discovery

相关期刊

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