Lifetime alcohol intake is associated with an increased risk of KRAS+ and BRAF-/KRAS- but not BRAF+ colorectal cancer.

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第一作者： Harindra,Jayasekara

第一单位： Cancer Council Victoria, Cancer Epidemiology Centre, 615 St Kilda Road, Melbourne, VIC, 3004, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia.

作者： Harindra,Jayasekara ^[1] ; Robert J,MacInnis ^[1] ; Elizabeth J,Williamson ^[2] ; Allison M,Hodge ^[3] ; Mark,Clendenning ^[4] ; Christophe,Rosty ^[5] ; Rhiannon,Walters ^[6] ; Robin,Room ^[7] ; Melissa C,Southey ^[8] ; Mark A,Jenkins ^[9] ; Roger L,Milne ^[1] ; John L,Hopper ^[1] ; Graham G,Giles ^[1] ; Daniel D,Buchanan ^[10] ; Dallas R,English ^[1]

作者单位： Cancer Council Victoria, Cancer Epidemiology Centre, 615 St Kilda Road, Melbourne, VIC, 3004, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. ^[1] Farr Institute of Health Informatics Research, London, NW1 2DA, United Kingdom.;Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, United Kingdom. ^[2] Cancer Council Victoria, Cancer Epidemiology Centre, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. ^[3] Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia. ^[4] Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia.;Envoi Specialist Pathologists, Brisbane, QLD, Australia.;School of Medicine, The University of Queensland, Brisbane, QLD, Australia. ^[5] Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia. ^[6] Centre for Alcohol Policy Research, La Trobe University, Melbourne, VIC, 3000, Australia.;Centre for Health Equity, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, 3010, Australia.;Centre for Social Research on Alcohol and Drugs, Stockholm University, Stockholm, SE-106 91, Sweden. ^[7] Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia. ^[8] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. ^[9] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia.;Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia. ^[10]

关键词 BRAF KRAS alcohol intake colorectal cancer