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Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule.

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第一作者： Justine,Thiry

第一单位： Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege, Quartier Hopital, Avenue Hippocrate 15, 4000, Liege, Belgium. Electronic address: jthiry@ulg.ac.be.

作者： Justine,Thiry ^[1] ; Miranda G M,Kok ^[2] ; Laurence,Collard ^[3] ; Antoine,Frère ^[3] ; Fabrice,Krier ^[3] ; Marianne,Fillet ^[2] ; Brigitte,Evrard ^[3]

作者单位： Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege, Quartier Hopital, Avenue Hippocrate 15, 4000, Liege, Belgium. Electronic address: jthiry@ulg.ac.be. ^[1] Laboratory for the Analysis of Medicines, CIRM, University of Liège, Quartier Hopital, Avenue Hippocrate 15, 4000, Liege, Belgium. ^[2] Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege, Quartier Hopital, Avenue Hippocrate 15, 4000, Liege, Belgium. ^[3]

关键词 And solid dispersion Bioavailability enhancement Biphasic dissolution test Cyclodextrin Volumetric absorptive microsampling devices